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Phosgene

  • -Mechanism of action? Structure? Clinical effects? Treatment? History?

  • -Causes a delayed ARDS type picture and respiratory irritation (typically around ppm>4.8).
  • -Causes acylation of cells in the alveoli as well as formation of ROS.  It is not readily water soluble so production of HOCl is less likely.
  • -Supportive care, high dose steroids, ARDS net protocol, but theoretically antioxidant support with NAC maybe of benefit, ECMO for complete lung failure
  • -History: chemical weapon used during World War 1

 

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