What are some common drugs metabolized through CYP2D6?
Why is this important?
Tramadol
Codeine
Opioids
TCA’s
Haloperidol
This is important because there is significant polymorphism in the world population with regards to this receptor. Some individuals have much more active CYP2D6 which leads to unpredictable metabolism, and possibly toxicity due to increased metabolites or decreased metabolism of the ingested xenobiotic.