Basic Tox Quiz Set

Quizes based on Goldfrank’s Toxicologic Emergencies 11e and other sources when cited in answer explanation.

One of the more important mechanism of action of arsenic is?

Displacing Cobalt from enzymes

Blocking intracellular calcium efflux/influx

Arsenic is incorporated in place of phosphorous, making various isomers of ADP-As, leading to instability of the ester bonds

Poisoning of mitochondrial cytochrome 4

Displacing Zinc from enzymes

What metal is the heaviest naturally occurring heavy metal by atomic weight?

Thallium

Palladium

Uranium

Neptunium

Plutonium

In acute iron toxicity, why is deferroxamine preferred to other chelators?

Stabilization of the reduced iron-deferroxamine complex

Stabilization of the oxidized iron-deferroxamine complex

EDTA, BAL, and succimer enhance fenton like reactions

Deferroxamine has more affinity to 3+ cations

EDTA, BAL, and succimer have a worse side effect profile

Which radioactive compound is utilized in nuclear stress testing?

Cesium

Radiolabeled glucose

Radiolabeled triglycerides

Thallium

Beryllium

Which of the following is a weak acid?

HCl

HBr

HAt

Which is the correct order of bond strength?

Ionic > covalent > van der waals > hydrogen bonds

Covalent > ionic > hydrogen bonds > van der waals

Ionic > covalent > hydrogen bonds > van der waals

Ionic > hydrogen bonds > covalent > van der waals

What is the ultimate metabolic pathway that leads to detoxicification of most free radical species?

Iron

NAPQI

Paraquat

Copper

Formaldehyde